Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 2.254


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX3chr5_+_1706688920.185.0e-01Click!
TLX1chr10_+_102881050-0.077.9e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27153892 3.090 NM_024014
HOXA6
homeobox A6
chr15_+_76889873 2.531 MORF4L1
mortality factor 4 like 1
chrX_-_128616594 2.507 NM_017413
APLN
apelin
chrX_-_53327473 2.308 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr5_+_38481392 2.203 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr22_-_37970902 2.199 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr19_+_10258642 2.029 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr1_-_151630168 1.846 NM_002964
S100A8
S100 calcium binding protein A8
chr3_+_46717826 1.825 NM_147196
TMIE
transmembrane inner ear
chr21_+_45699830 1.821 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr14_+_72773957 1.790 NM_173462
NDRG2
PAPLN
NDRG family member 2
papilin, proteoglycan-like sulfated glycoprotein
chrX_-_129347101 1.719 NM_178471
GPR119
G protein-coupled receptor 119
chr1_+_219026661 1.713 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr17_-_928960 1.653 ABR
active BCR-related gene
chr19_+_10404110 1.650 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr22_+_40093245 1.625 NM_001145398
TEF
thyrotrophic embryonic factor
chr9_+_135389698 1.546 NM_014694
ADAMTSL2
ADAMTS-like 2
chr15_-_66511488 1.523 NM_001004439
ITGA11
integrin, alpha 11
chr6_+_167658563 1.520 NM_031949
TTLL2
tubulin tyrosine ligase-like family, member 2
chr17_+_75507750 1.511


chr11_+_74539679 1.437 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chrX_-_13866451 1.390 GPM6B
glycoprotein M6B
chr7_-_150283794 1.295 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr13_+_112670757 1.286 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr19_+_51498695 1.263 NM_152794
HIF3A
hypoxia inducible factor 3, alpha subunit
chr7_+_102340579 1.245 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr1_-_41722883 1.232 NM_001956
EDN2
endothelin 2
chrX_-_118168569 1.227 NM_020721
KIAA1210
KIAA1210
chr19_-_38408449 1.211 NM_019849
SLC7A10
solute carrier family 7, (neutral amino acid transporter, y+ system) member 10
chr9_-_112010233 1.187 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr1_+_183970093 1.185 NM_031935
HMCN1
hemicentin 1
chrX_+_122922058 1.164 NM_001042749
STAG2
stromal antigen 2
chr1_+_78858675 1.159 NM_006820
IFI44L
interferon-induced protein 44-like
chr16_+_56219802 1.148 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr7_-_36991189 1.145 NM_001039459
ELMO1
engulfment and cell motility 1
chr17_-_74432671 1.141 TIMP2
TIMP metallopeptidase inhibitor 2
chrX_-_13866366 1.133


chrX_+_153423652 1.125 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr8_-_18585721 1.124 PSD3
pleckstrin and Sec7 domain containing 3
chr15_-_81412354 1.117 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr19_+_3659358 1.089 TJP3
tight junction protein 3 (zona occludens 3)
chr7_-_99411573 1.088 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr17_-_72045218 1.063 NM_134268
CYGB
cytoglobin
chr3_+_127743868 1.063 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr22_-_29290875 1.062 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr3_-_58538110 1.062 FAM107A
family with sequence similarity 107, member A
chr14_+_69021149 1.061 NM_001161498
UPF0639
UPF0639 protein
chr19_+_15612706 1.044 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr9_-_139183675 1.006


chr1_-_23683214 0.963 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chrX_-_13866565 0.946 NM_001001994
GPM6B
glycoprotein M6B
chr19_+_40849554 0.945 NM_007000
UPK1A
uroplakin 1A
chr8_-_27524744 0.938 NM_203339
CLU
clusterin
chrX_-_110541029 0.925 NM_000555
DCX
doublecortin
chr7_+_142205266 0.920


chr6_-_43703024 0.906 GTPBP2
GTP binding protein 2
chr16_-_30032330 0.902 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr1_-_245342150 0.901 NM_207401
C1orf229
chromosome 1 open reading frame 229
chr12_-_50871953 0.888 NM_001081492
NM_182507
KRT80

keratin 80

chr6_-_43703057 0.868 GTPBP2
GTP binding protein 2
chr11_-_118716736 0.863 C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr7_-_143587653 0.809 NM_001005328
OR2A7
OR2A4
olfactory receptor, family 2, subfamily A, member 7
olfactory receptor, family 2, subfamily A, member 4
chr19_+_60035942 0.809 NM_012314
KIR2DS4
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
chr17_-_74432800 0.806 TIMP2
TIMP metallopeptidase inhibitor 2
chr3_+_52325374 0.791 NM_015512
DNAH1
dynein, axonemal, heavy chain 1
chr19_-_8581559 0.775 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chrX_-_132947141 0.774 GPC3
glypican 3
chr19_-_53950458 0.774 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr22_-_29197944 0.770 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr7_-_151205142 0.761 NM_016203
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr19_-_46048033 0.760 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr4_-_155632317 0.759 NM_001142552
NM_001142553
DCHS2

dachsous 2 (Drosophila)

chr1_-_218168548 0.758 NM_018713
SLC30A10
solute carrier family 30, member 10
chr17_-_74433048 0.757 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr12_-_47031287 0.754 NM_001172682
ZNF641
zinc finger protein 641
chr21_+_44761927 0.751 C21orf90
chromosome 21 open reading frame 90
chr19_+_51493486 0.747 NM_022462
HIF3A
hypoxia inducible factor 3, alpha subunit
chrX_-_132947290 0.745 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr10_+_685887 0.745 C10orf108
chromosome 10 open reading frame 108
chr16_+_2746363 0.739


chr1_-_199259447 0.739 NM_017596
KIF21B
kinesin family member 21B
chr8_-_27525084 0.734 NM_001171138
CLU
clusterin
chr22_+_43451351 0.725 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr7_+_142723340 0.724 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr20_+_34206070 0.723 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr1_-_1840564 0.723 NM_178545
TMEM52
transmembrane protein 52
chr19_+_4442610 0.718 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr1_-_199259133 0.714 KIF21B
kinesin family member 21B
chr9_+_130719034 0.709 LRRC8A
leucine rich repeat containing 8 family, member A
chr3_+_42107711 0.693 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr15_+_72828235 0.692 NM_000761
CYP1A2
cytochrome P450, family 1, subfamily A, polypeptide 2
chr6_+_29663661 0.690 NM_007160
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr1_-_111848265 0.690 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr19_+_59973074 0.689 NM_014218
KIR2DS2
KIR2DL1
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
chr6_-_30236667 0.688 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr2_+_108604111 0.686 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr10_+_26263163 0.684 MYO3A
myosin IIIA
chrX_-_114703273 0.684


chr17_-_4410565 0.669 NM_001122890
NM_153338
GGT6

gamma-glutamyltransferase 6

chr17_-_77394872 0.665 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr17_-_4491694 0.656 NM_001140
ALOX15
arachidonate 15-lipoxygenase
chr17_-_44226595 0.655 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr20_+_41628150 0.648 NM_016276
SGK2
serum/glucocorticoid regulated kinase 2
chr1_+_151015471 0.647 NM_178354
LCE1F
late cornified envelope 1F
chr4_+_86968069 0.641 ARHGAP24
Rho GTPase activating protein 24
chr13_-_24643620 0.638 FAM123A
family with sequence similarity 123A
chr1_-_227636462 0.636 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr16_+_55456619 0.627 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr7_+_128142661 0.621 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr9_-_139184247 0.620 NM_001013653
LRRC26
leucine rich repeat containing 26
chr9_-_123302126 0.620 GGTA1
glycoprotein, alpha-galactosyltransferase 1 pseudogene
chrX_+_106048245 0.619 NM_001171095
CLDN2
claudin 2
chr20_+_43468046 0.616 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr14_-_104142125 0.611 NM_207379
TMEM179
transmembrane protein 179
chrX_+_152423277 0.606 BGN
biglycan
chr22_+_21065202 0.606


chr1_+_116181927 0.606 NHLH2
nescient helix loop helix 2
chrX_+_133952633 0.605 NM_001163438
LOC644538
hypothetical protein LOC644538
chr5_-_176763991 0.600 F12
coagulation factor XII (Hageman factor)
chr6_-_3390197 0.599 NM_021945
SLC22A23
solute carrier family 22, member 23
chr11_+_119616112 0.598 NM_014352
POU2F3
POU class 2 homeobox 3
chrX_+_106057984 0.597 CLDN2
claudin 2
chr10_+_82163568 0.592 C10orf58
chromosome 10 open reading frame 58
chr2_+_26924466 0.584 NM_020134
DPYSL5
dihydropyrimidinase-like 5
chr17_+_24394281 0.583 PIPOX
pipecolic acid oxidase
chr2_+_242400702 0.581 NM_001167599
NM_001167602
NM_080741
NEU4


sialidase 4


chr22_+_21065134 0.578 LOC100290481
immunoglobulin lambda light chain-like
chr5_-_36278000 0.577 NM_153013
C5orf33
chromosome 5 open reading frame 33
chr3_+_42675841 0.575 ZBTB47
zinc finger and BTB domain containing 47
chr14_+_105063975 0.573 NM_025268
TMEM121
transmembrane protein 121
chr10_+_135010833 0.572 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr1_-_151804929 0.570 NM_005978
S100A2
S100 calcium binding protein A2
chr10_-_51156329 0.567 NM_001077685
AGAP4
AGAP7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 7
chr5_+_176449156 0.564 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr17_+_4795128 0.562 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr16_-_49742651 0.558 NM_002968
SALL1
sal-like 1 (Drosophila)
chr6_-_28429950 0.553 NM_145909
ZNF323
zinc finger protein 323
chr9_+_138726737 0.552 NM_152421
FAM69B
family with sequence similarity 69, member B
chr1_+_16247870 0.545 NM_001165945
CLCNKB
chloride channel Kb
chr1_+_18680010 0.545 NM_152375
KLHDC7A
kelch domain containing 7A
chr15_+_64781723 0.544 NM_005585
SMAD6
SMAD family member 6
chr19_+_49894260 0.544 NM_001039213
CEACAM16
carcinoembryonic antigen-related cell adhesion molecule 16
chr11_-_56846246 0.544 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr12_-_4425040 0.538 NM_020996
FGF6
fibroblast growth factor 6
chr3_+_38007264 0.536 VILL
villin-like
chr17_+_7125702 0.534 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr8_+_55533047 0.533 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr6_-_31853027 0.532 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr1_-_218168404 0.529


chr17_+_24394043 0.528 NM_016518
PIPOX
pipecolic acid oxidase
chr16_-_3025542 0.526 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr11_-_33870411 0.524 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_10672079 0.523 NM_001100163
NM_130385
MRVI1

murine retrovirus integration site 1 homolog

chr6_-_68655708 0.520


chr12_+_99391681 0.520 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr22_+_21065207 0.519 IGLJ3
immunoglobulin lambda joining 3
chr1_-_92722088 0.518 GFI1
growth factor independent 1 transcription repressor
chr8_-_22841173 0.517 NM_144962
PEBP4
phosphatidylethanolamine-binding protein 4
chr9_+_138991775 0.516 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr11_-_30564338 0.514 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr16_-_19803606 0.513 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr11_-_69299351 0.509 NM_002007
FGF4
fibroblast growth factor 4
chr20_+_55569542 0.508 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr11_-_117600918 0.501 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chrX_+_2756810 0.498 NM_001079855
NM_001184702
NM_001184703
NM_001184704
NM_003918
GYG2




glycogenin 2




chr11_-_35397090 0.497 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chrX_-_54841397 0.493 NM_198510
ITIH5L
inter-alpha (globulin) inhibitor H5-like
chr19_-_40325194 0.493 LGI4
leucine-rich repeat LGI family, member 4
chrX_-_71268475 0.493 NM_001024455
RGAG4
retrotransposon gag domain containing 4
chr1_+_78888064 0.491 NM_006417
IFI44
interferon-induced protein 44
chr19_+_15644885 0.489 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr6_+_132170888 0.488 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr1_-_158306570 0.487 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chrX_-_40391610 0.487 CXorf38
chromosome X open reading frame 38
chr8_-_145672525 0.486 NM_003923
FOXH1
forkhead box H1
chr6_-_39305203 0.486 NM_003740
KCNK5
potassium channel, subfamily K, member 5
chr2_-_96314148 0.485 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr9_+_138991835 0.477 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr13_+_97593411 0.474 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr12_-_47030820 0.473 NM_001172681
NM_152320
ZNF641

zinc finger protein 641

chr16_+_2071631 0.472 TSC2
tuberous sclerosis 2
chr22_+_18085990 0.471 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chrX_-_8660170 0.470 NM_000216
KAL1
Kallmann syndrome 1 sequence
chr16_+_273118 0.470 NM_006849
PDIA2
protein disulfide isomerase family A, member 2
chr1_+_61319976 0.469 NM_001145512
NFIA
nuclear factor I/A
chr11_-_1973319 0.468 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_-_4747147 0.465 NM_000080
CHRNE
cholinergic receptor, nicotinic, epsilon
chr11_-_64266916 0.465


chr11_-_118757574 0.464 NM_004205
USP2
ubiquitin specific peptidase 2
chr3_-_127558747 0.463 NM_014079
KLF15
Kruppel-like factor 15
chr1_-_156078115 0.462 NM_005894
CD5L
CD5 molecule-like
chr17_-_3129017 0.459 NM_002551
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr17_-_64823368 0.459 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr10_+_26263007 0.459 NM_017433
MYO3A
myosin IIIA
chr3_-_31997738 0.458 OSBPL10
oxysterol binding protein-like 10
chr10_-_105604942 0.454 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chrX_+_49013243 0.450 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory (inhibitor) subunit 3F

chr10_-_71871364 0.448 NODAL
nodal homolog (mouse)
chr1_+_32447281 0.447 NM_001099434
DCDC2B
doublecortin domain containing 2B
chr22_-_40666168 0.446 NM_001110215
CENPM
centromere protein M

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.93 6.77e-03 GO:0032312 regulation of ARF GTPase activity
4.47 2.05e-02 GO:0032012 regulation of ARF protein signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 6.11e-05 GO:0044459 plasma membrane part
1.59 1.09e-03 GO:0044421 extracellular region part
1.46 1.25e-02 GO:0031226 intrinsic to plasma membrane
1.46 1.48e-02 GO:0005887 integral to plasma membrane
1.22 1.87e-02 GO:0005886 plasma membrane
1.22 2.33e-02 GO:0071944 cell periphery
1.33 3.24e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.93 1.60e-03 GO:0008060 ARF GTPase activator activity